Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10250-1 | 500 µl | - |
6 - 10 business days* |
422.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Programmed cell death protein 4 (PDCD4) levels are elevated during apoptosis and absent in many... more
Product information "Anti-Programmed Cell Death Protein 4 (C-Term)"
Programmed cell death protein 4 (PDCD4) levels are elevated during apoptosis and absent in many cancer samples. Loss of PDCD4 expression is an important event in cancer cell progression whereas the restoration of PDCD4 protein can lower metalloproteinase activity and possible metastasis. The known isoforms of PDCD4 differ only at the N-terminial with isoform 1 comprised of 468 amino acids and isoform 2 comprised of 458 amino acids. Each isoform contains two MA-3 domains essential for binding of PDCD4 binding to eIF4A, thereby suppressing cell cycle regulation and growth factor production. This antibody is capable of detecting both PDCD4 isoforms. Additional protein modifications are possible and can explain the range of masses detected by immunoblotting (52-64 kDa). The molecular mechanisms of PDCD4 influence on tumor suppression are becoming known but warrant further research.Synonyms: Neoplastic Transformation Inhibitor, PDCD4. Immunogen: Synthetic peptide from the C-terminal region of human protein. Formulation: (Request formulation change), 500 µl of peptide-affinity purified polyclonal antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azid. Host: Rabbit. Applications: WB. UniProt Accession #: Q53EL6. Origin: Animal/Rabbit.
Keywords: | Anti-H731, Anti-PDCD4, Anti-Protein 197/15a, Anti-Protein 197/15a, Anti-Nuclear antigen H731-like, Anti-Nuclear antigen H731-like, Anti-Programmed cell death protein 4, Anti-Programmed cell death protein 4, Anti-Neoplastic transformation inhibitor protein |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10250 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide from the C-terminal region of human protein |
Format: | Peptide Affinity Purified |
Database Information
KEGG ID : | K16865 | Matching products |
UniProt ID : | Q53EL6 | Matching products |
Gene ID | GeneID 27250 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed