Anti-PRKAR2B, ID (PRKAR2B, cAMP-dependent protein kinase type II-beta regulatory subunit)

Anti-PRKAR2B, ID (PRKAR2B, cAMP-dependent protein kinase type II-beta regulatory subunit)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
040444.200 200 µl - -

1 - 19 business days

557.00€
 
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its... more
Product information "Anti-PRKAR2B, ID (PRKAR2B, cAMP-dependent protein kinase type II-beta regulatory subunit)"
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq]. Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-PRKAR2B, Anti-cAMP-dependent protein kinase type II-beta regulatory subunit
Supplier: United States Biological
Supplier-Nr: 040444

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: PRKAR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 amino acids from the Central region of human PRKAR2B.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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