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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V4095SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. This gene encodes a multifunctional protein that... more
Product information "Anti-POGZ / Pogo transposable element with ZNF domain, clone PCRP-POGZ-1B2"
1 mg/ml in 1X PBS, BSA free, sodium azide free. This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. Protein function: Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). [The UniProt Consortium]
Keywords: | Anti-POGZ, Anti-KIAA0461, Anti-Nbla00003, Anti-Zinc finger protein 635, Anti-Zinc finger protein 280E, Anti-Suppressor of hairy wing homolog 5, Anti-Pogo transposable element with ZNF domain, POGZ Antibody / Pogo transposable element with ZNF domain |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V4095SAF |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | PCRP-POGZ-1B2 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant full-length human Pogo transposable element with ZNF domain protein |
Format: | Purified |
Database Information
KEGG ID : | K22594 | Matching products |
UniProt ID : | Q7Z3K3 | Matching products |
Gene ID | GeneID 23126 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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