Anti-PIN1

Anti-PIN1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-315A-T 10 µl (10 µg) -

6 - 10 business days*

131.00€
A302-315A 100 µl (100 µg) -

6 - 10 business days*

465.00€
 
Protein function: Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes... more
Product information "Anti-PIN1"
Protein function: Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr- Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, Ref. 21). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). [The UniProt Consortium]
Keywords: Anti-PIN1, EC=5.2.1.8, Anti-PPIase Pin1, Anti-Rotamase Pin1, Anti-Peptidyl-prolyl cis-trans isomerase Pin1, Anti-Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-315A

Properties

Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Bovine)
Immunogen: synthetic peptide. The epitope recognized by A302-315A-T maps to a region between residue 50 and 100 of human protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 using the numbering given in entry NP_006212.1 (GeneID 5300).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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