Anti-Phosphoinositide 3 Kinase Enhancer (PIKE, Centaurin gamma 1)

Anti-Phosphoinositide 3 Kinase Enhancer (PIKE, Centaurin gamma 1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P4073-38.100 100 µg - -

3 - 19 business days*

644.00€
 
Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts... more
Product information "Anti-Phosphoinositide 3 Kinase Enhancer (PIKE, Centaurin gamma 1)"
Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity (1). PIKE exists in multiple isoforms, a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1 (reviewed in 2). The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis (3). Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes (4). In many human cancers, expression of PIKE-A is enhanced, leading to increased Akt activity and preventing apoptosis. Applications: Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml, Immunohistochemistry: Immunohistochemistry of PIKE in mouse brain tissue with PIKE antibody at 10ug/ml., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-GGAP2, Anti-AGAP2, Anti-Cnt-g1, Anti-AGAP-2, Anti-CENTG1, Anti-Centaurin-gamma-1, Anti-Phosphatidylinositol-3-kinase enhancer, Anti-GTP-binding and GTPase-activating protein 2, Anti-Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Supplier: United States Biological
Supplier-Nr: P4073-38

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Format: Highly Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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