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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
P3122-15A.100 | 100 µl | - | - |
3 - 19 business days* |
1,022.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The mammalian protein disulfide-isomerase (PDI) family encompasses several highly divergent... more
Product information "Anti-PDI (Protein Disulfide Isomerase), clone 6D648"
The mammalian protein disulfide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulfide bonds. PDI, an abundant protein of the ER (> 400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing and one domain lacking a redox-active-Cys-X-X-Cys-tetrapeptide. In addition to their roles as redox catalysts and isomerases, PDI proteins have other functions such as peptide binding, cell adhesion and perhaps chaperone activities. Platelet surface thiols and disulfides play an important role in platelet responses. Catalytically active PDI is found on platelet surfaces where it has been demonstrated to mediate platelet aggregation and secretion possible by reducing disulfide bonds thus leading to exposure of fibrinogen receptors in platelets. Applications: Suitable for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immnoprecipitation, Western Blot, and Functional Applications. Other applications have not been tested. Recommended Dilutions: Immunocytochemistry: 1:100, Immunohistochemistry (Frozen and parafffin): 1:100, Western Blot: 1:1000, Optimal dilution to be determined by the end-user. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: | United States Biological |
Supplier-Nr: | P3122-15A |
Properties
Application: | FC, ICC, IHC, IP, WB |
Antibody Type: | Monoclonal |
Clone: | 6D648 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | hamster, human, mouse, swine, rat |
Immunogen: | Purified rat liver PDI (protein disulphide-isomerase). |
Database Information
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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