Anti-PDCD1 / PD-1 / PD1, clone RMPD1-1

Anti-PDCD1 / PD-1 / PD1, clone RMPD1-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7204IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-PDCD1 / PD-1 / PD1, clone RMPD1-1"
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. Programmed cell death protein 1 is an inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. [UniProt] Protein function: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. [The UniProt Consortium]
Keywords: Anti-hPD-1, Anti-CD279, Anti-Protein PD-1, Anti-Programmed cell death protein 1, PDCD1 Antibody / PD-1 / PD1
Supplier: NSJ Bioreagents
Supplier-Nr: V7204IHC

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: RMPD1-1
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A full length recombinant human protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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