Anti-PD-1, clone YN01296m

Tumor cells can be recognized by the immune system and even eliminated. PD-1 is expressed in activated T cells and tumor infiltrating lymphocytes involved in tumor cell immunity, while tumor cells express PD-L1 and PD-L2 ligands of PD-1 in their microenvironment to complete immune escape. This is widely used in the detection of PD-1 in various tumor tissues and their microenvironment, which can help the application of targeted drugs. Protein function: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. [The UniProt Consortium]