Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-979A-T 10 µl (10 µg) -

3 - 9 business days*

A301-979A 100 µl (100 µg) -

3 - 9 business days*

Protein function: Its association with the histone methyltransferase MLL2/MLL3 complex is... more
Product information "Anti-PA1"
Protein function: Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG, the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). [The UniProt Consortium]
Keywords: Anti-GAS, Anti-PAGR1, Anti-C16orf53, Anti-PTIP-associated protein 1, Anti-PAXIP1-associated protein 1, Anti-PAXIP1-associated glutamate-rich protein 1, Anti-Glutamate-rich coactivator interacting with SRC1
Supplier: Bethyl Laboratories
Supplier-Nr: A301-979A


Application: IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Horse, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Chinese Hamster, Small-eared Galago, Thirteen-lined Ground Squirrel, Little Brown Bat)
Immunogen: synthetic peptide. The epitope recognized by A301-979A-T maps to a region between residue 204 and 254 of human PTIP-associated 1 protein using the numbering given in entry NP_078792.1 (GeneID 79447).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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