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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F48734-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F48734-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. Catalyzes poly (ADP-ribose) protein modification,... more
Product information "Anti-p-PARP-1 (pS373)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Catalyzes poly (ADP-ribose) protein modification, plays a role in DNA repair and genome stability [RGD]. Protein function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. [The UniProt Consortium]
Keywords: | Anti-ARTD1, Anti-Adprt, Anti-Parp1, Anti-PARP-1, Anti-ADPRT 1, EC=2.4.2.30, Anti-Poly[ADP-ribose] synthase 1, Anti-Poly [ADP-ribose] polymerase 1, Anti-NAD(+) ADP-ribosyltransferase 1, Anti-ADP-ribosyltransferase diphtheria toxin-like 1, p-PARP-1 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F48734 |
Properties
Application: | Dot Blot, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | rat |
Immunogen: | This p-PARP-1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS373 of rat PARP1. |
Format: | Purified |
Database Information
KEGG ID : | K24070 | Matching products |
UniProt ID : | P27008 | Matching products |
Gene ID | GeneID 25591 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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