Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R31714 100 µg - -

3 - 10 business days

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Numb is a protein that in humans is... more
Product information "Anti-Numb"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Numb is a protein that in humans is encoded by the gene of the same name. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. Additionally, the protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis. Protein function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. [The UniProt Consortium]
Keywords: Anti-NUMB, Anti-h-Numb, Anti-Protein S171, Anti-Protein numb homolog, Numb Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R31714


Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Amino acids 194-220 (SFRVTTATEQAEREEIMKQMQDAKKAE-human) were used as the immunogen for this Numb antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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