Anti-NMDAR2B / GRIN2B

Anti-NMDAR2B / GRIN2B
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R32209 100 µg - -

3 - 10 business days

503.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The N-methyl-D-aspartate receptor 2B... more
Product information "Anti-NMDAR2B / GRIN2B"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The N-methyl-D-aspartate receptor 2B (NMDAR2B), also names as GRIN2B. The sequence of the predicted 1,484-amino acid human protein is 98% and 96% identical to the sequences of the rat and mouse Nmdar2b proteins, respectively. Nmdar2B gene is located on mouse chromosome 6 between Rho and Ly49 centromerically and Glb telomerically. Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12 overexpression of NMDA receptor 2B (NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic potentiation in response to stimulation at 10-100 Hz. Protein function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. [The UniProt Consortium]
Keywords: Anti-NR3, Anti-hNR3, Anti-NR2B, Anti-GRIN2B, Anti-GluN2B, Anti-NMDAR2B, Anti-Glutamate receptor ionotropic, NMDA 2B, Anti-N-methyl-D-aspartate receptor subunit 3, Anti-N-methyl D-aspartate receptor subtype 2B, NMDAR2B Antibody / GRIN2B
Supplier-Nr: R32209

Properties

Application: WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Amino acids 1076-1332 of human NMDAR2B were used as the immunogen for the NMDAR2B antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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