Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay13757-1 | 1 each | - |
6 - 10 business days* |
395.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
NF-kappaB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-kappaB... more
Product information "Anti-NF-kappaB (p65) (aa 2-17)"
NF-kappaB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-kappaB complex and is encoded by the RELA gene in humans. It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65. NF-kappaB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation. Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1beta and TNF-alpha induced by LPS. Genome-wide deletion of Rela in mice is embryonic lethal. NF-kappaB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-kappaB p65. Cayman's NF-?B (p65) Polyclonal Antibody (aa 2-17) can be used for Western blot (WB) applications. The antibody recognizes amino acids 2-17 of NF-kappaB (p65) at 60 kDa from human, chimpanzee, and monkey samples.Synonyms: Nuclear Factor NF-kappaB (p65) subunit, Transcription Factor p65. Immunogen: Synthetic peptide from the N-terminal region of human NF-kappaB (p65). MW: 60 kDa. Formulation: (Request formulation change), 100 µg of protein G-purified IgG. Storage Buffer: 200 µl PBS, with 0.2% gelatin and 0.05% sodium azide. Host: Rabbit. Applications: WB. Origin: Animal/Rabbit.
Keywords: | Nuclear Factor NF-kappaB (p65) subunit, Transcription Factor p65 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 13757 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide from the N-terminal region of human NF-?B (p65) |
Format: | Purified |
Database Information
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed