Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay33679-100 | 100 µg | - |
6 - 10 business days* |
422.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
LL-37 is a cationic alpha-helical peptide expressed in human bone marrow, testis, granulocytes,... more
Product information "Anti-LL-37 (Clone 3G10)"
LL-37 is a cationic alpha-helical peptide expressed in human bone marrow, testis, granulocytes, gingival epithelium, and a variety of immune cells. It is produced by proteolytic cleavage of the cathelicidin human cationic antimicrobial protein of 18 kDa (hCAP18). LL-37 has antimicrobial and antiviral activity, and protein levels of LL-37 are increased in epithelial cells, macrophages, and neutrophils following bacterial infection in vitro. It functions as a chemoattractant for human monocytes, neutrophils, and T cells, and induces chemokine secretion from epithelial cells in infected tissues. LL-37 is a component of LPS-induced neutrophil extracellular traps (NETs) produced from human neutrophils isolated from patients with systemic lupus erythrematosus (SLE) or individuals without SLE. It also enhances formation of NETs induced by phorbol 12-myristate 13-acetate (PMA) or S. aureus. LL-37 can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4, a modification that reduces its antibacterial and antiviral activities. Native, but not citrullinated, LL-37 prevents mortality in a mouse model of D-galactosamine-sensitized endotoxic shock. Cayman's LL-37 Monoclonal Antibody (Clone 3G10) can be used for ELISA and flow cytometry (FC) applications.Synonyms: Antibacterial Protein LL-37. Immunogen: Synthetic human LL-37. Clone Designation: 3G10. Formulation: (Request formulation change), 100 µg of protein G-affinity purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA, FC. Cross Reactivity: (+) LL-37, (+) hCAP18. UniProt Accession #: P49913.
Keywords: | Anti-HSD26, Anti-CAP-18, Anti-hCAP-18, Anti-FALL-39 peptide antibiotic, Anti-Antibacterial peptide LL-37, Anti-Antibacterial peptide FALL-39, Anti-Cathelicidin antimicrobial peptide, Anti-18 kDa cationic antimicrobial protein |
Supplier: | Cayman Chemical |
Supplier-Nr: | 33679 |
Properties
Application: | ELISA, FC |
Antibody Type: | Monoclonal |
Clone: | 3G10 |
Conjugate: | No |
Host: | Mouse |
Immunogen: | Synthetic human LL-37 |
Format: | Purified |
Database Information
KEGG ID : | K13916 | Matching products |
UniProt ID : | P49913 | Matching products |
Gene ID | GeneID 820 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed