Anti-Lipin 1 (LPIN1, DKFZp781P1796, KIAA0188)

Anti-Lipin 1 (LPIN1, DKFZp781P1796, KIAA0188)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
L2497-01F.100 100 µl - -

3 - 19 business days*

498.00€
 
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of... more
Product information "Anti-Lipin 1 (LPIN1, DKFZp781P1796, KIAA0188)"
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1alpha, target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance. Cellular Localization: Nuclear , Positive Control: 3T3-L1 cell lysates. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: L2497-01F

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: A synthetic peptide to an internal region (within residues 500-600) of the human LPIN1 protein. [Swiss-Prot# Q14693]. Homology: 100% homology with human protein, 82% with mouse protein, and 76% with rat protein.
Purity: Purified by peptide immunoaffinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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