Anti-LATS2

Promotion:

For a limited time, purchase an Elabscience primary antibody (size 60 μl and up) and receive a free secondary antibody of the same size.

*1
*1 Offer expires 30/04/2020
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-15942.20 20 µl - -

7 - 16 business days

63.00€
E-AB-15942.60 60 µl - -

7 - 16 business days

119.00€
E-AB-15942.120 120 µl - -

7 - 16 business days

211.00€
E-AB-15942.200 200 µl - -

7 - 16 business days

367.00€
 
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor... more
Product information "Anti-LATS2"
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. Protein function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. [The UniProt Consortium]
Keywords: Anti-KPM, EC=2.7.11.1, Anti-Warts-like kinase, Anti-Large tumor suppressor homolog 2, Anti-Serine/threonine-protein kinase kpm, Anti-Serine/threonine-protein kinase LATS2, Anti-Kinase phosphorylated during mitosis protein, LATS2 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-15942

Properties

Application: IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide of human LATS2
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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