Anti-Ku70 + Ku80 PE Conjugate, clone LKAP1-1

Anti-Ku70 + Ku80 PE Conjugate, clone LKAP1-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7202PE-100T 100 tests - -

3 - 10 business days*

752.00€
 
500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Protein function:... more
Product information "Anti-Ku70 + Ku80 PE Conjugate, clone LKAP1-1"
500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Protein function: Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. [The UniProt Consortium]
Keywords: Anti-TLAA, Anti-Ku70, Anti-G22P1, Anti-CTC75, Anti-XRCC6, Anti-CTCBF, EC=3.6.4.-, EC=4.2.99.-, Anti-5'-dRP lyase Ku70, Anti-DNA repair protein XRCC6, Anti-Thyroid-lupus autoantigen, Anti-70 kDa subunit of Ku antigen, Anti-Lupus Ku autoantigen protein p70
Supplier: NSJ Bioreagents
Supplier-Nr: V7202PE

Properties

Application: FC
Antibody Type: Monoclonal
Clone: LKAP1-1
Conjugate: Phycoerythrin
Host: Mouse
Species reactivity: human
Immunogen: A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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