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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V7202-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V7202-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Protein function: Single-stranded... more
Product information "Anti-Ku70 + Ku80, clone LKAP1-1"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Protein function: Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. [The UniProt Consortium]
Keywords: | Anti-TLAA, Anti-Ku70, Anti-G22P1, Anti-CTC75, Anti-XRCC6, Anti-CTCBF, EC=3.6.4.-, EC=4.2.99.-, Anti-5'-dRP lyase Ku70, Anti-DNA repair protein XRCC6, Anti-Thyroid-lupus autoantigen, Anti-70 kDa subunit of Ku antigen, Anti-Lupus Ku autoantigen protein p70 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V7202 |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | LKAP1-1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K10884 | Matching products |
UniProt ID : | P12956 | Matching products |
Gene ID | GeneID 2547 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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