Anti-KPNA3

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-626A 100 µl (20 µg) -

3 - 9 business days

443.00€
 
Protein function: Functions in nuclear protein import as an adapter protein for nuclear receptor... more
Product information "Anti-KPNA3"
Protein function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. [The UniProt Consortium]
Keywords: Anti-QIP2, Anti-Qip2, Anti-KPNA3, Anti-SRP1-gamma, Anti-Importin alpha Q2, Anti-Importin subunit alpha-4, Anti-Karyopherin subunit alpha-3
Supplier: Bethyl Laboratories
Supplier-Nr: A301-626A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rhesus Monkey, Chimpanzee, White-tufted-ear Marmoset, Small-eared Galago)
Immunogen: synthetic peptide. The epitope recognized by A301-626A maps to a region between residue 1 and 50 of human karyopherin alpha 3 using the numbering given in entry NP_002258.2 (GeneID 3839).
Format: Antigen Affinity Purified

Database Information

UniProt ID : O00505 | Find alternatives
Gene ID GeneID 3839 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-KPNA3"
Write a review
or to review a product.
Viewed