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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F40314-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F40314-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a protein containing KELCH-1 like... more
Product information "Anti-KEAP1, clone 297CT6.1.6"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. Protein function: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. [The UniProt Consortium]
Keywords: | Anti-INrf2, Anti-INRF2, Anti-KEAP1, Anti-Kelch-like protein 19, Anti-Cytosolic inhibitor of Nrf2, Anti-Kelch-like ECH-associated protein 1, KEAP1 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F40314 |
Properties
Application: | WB, ELISA |
Antibody Type: | Monoclonal |
Clone: | 297CT6.1.6 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A portion of amino acids 422-449 from the human protein was used as the immunogen for this KEAP1 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K10456 | Matching products |
UniProt ID : | Q14145 | Matching products |
Gene ID | GeneID 9817 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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