Anti-KDM4A / JHDM3A

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Discount	Price
ARG40746.100	100 µl		-	-	6 - 14 business days*		30 %	624.00€ 436.80€

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Protein function: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36'... more

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Product information "Anti-KDM4A / JHDM3A"

Protein function: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. [The UniProt Consortium]

Keywords:	Anti-KDM4A, Anti-JHDM3A, EC=1.14.11.-, Anti-Lysine-specific demethylase 4A, Anti-Jumonji domain-containing protein 2A, Anti-JmjC domain-containing histone demethylation protein 3A
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40746

Properties

Application:	IHC (paraffin), IP, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Synthetic peptide derived from Human KDM4A / JHDM3A
MW:	120 kD
Format:	Affinity Purified