134 products were found matching "K06709"!

Protein function: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no...

Protein function: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and...

2-(1H-Pyrazol-3-yl)pyridine-4-carboxylic acid is a heterocycle that has been used as a cofactor in crystallography studies of lysine-specific demethylase 4A (KDM4A), also known as Jumanji domain containing 2A (JMJD2A). InChI: InChI=1S/C9H7N3O2.ClH/c13-9(14)6-1-3-10-8(5-6)7-2-4-11-12-7,/h1-5H,(H,11,12)(H,13,14),1H...

Rabbit Polyclonal KDM4D Antibody against Human lysine demethylase 4D. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000053914: 84%, ENSRNOG00000045905:...

A KDM4 inhibitor, selective for KDM4A, KDM4B, KDM4C, and KDM4D (IC50s = 104, 56, 35, and 104 nM, respectively) over KDM2B, KDM3A, KDM3B, KDM6B, and PHF8 (IC50s = >4,000 nM for all) but does inhibit KDM5B (IC50 = 750 nM), increases H3K36Me3 levels in KYSE-150 cells (EC50 = 1.3 nM), reduces the proliferation of...

Protein function: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no...

The jumonji domain-containing protein 2 (JMJD2) subfamily of histone demethylases have been shown to catalyze demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 in vitro and in cells. Because histone demethylases are implicated in certain diseases, including cancer, selective inhibitors are...

Protein function: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and...

Active human JMJD2C (GenBank Accession No. BC143571) (amino-acids 2-372) with N-terminal GST tag, MW=69 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Replaces JMJD2A, #BPS-50103, a.a. 1-480. Human JMJD2A, also known as JHDM3A and KDM4A (GenBank Accession No. NM_014663) (amino-acids 1-350) with N-terminal His-tag, MW=42 kDa, expressed in an E.coli expression system.

Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD3 with IC50 values of approximately 4.3, 3.4, 5.9, 10, and 43 µM, respectively, in an in vitro...

Jumonji Domain Containing 2A (JMJD2A) is a lysine-specific demethylase that catalyzes the demethylation of histone H3 at lysine residues 9 and 36 and histone H1.4 at lysine residue 26. It is composed of the JmjN N-terminal domain, JmjC catalytic domain, two plant homeodomains (PHDs), and two tudor domains that...