Anti-IRF3

Anti-IRF3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-384A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-384A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-384A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Key transcriptional regulator of type I interferon (IFN)-dependent immune... more
Product information "Anti-IRF3"
Protein function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. [The UniProt Consortium]
Keywords: Anti-Irf3, Anti-IRF-3, Anti-Interferon regulatory factor 3
Supplier: Bethyl Laboratories
Supplier-Nr: A303-384A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Mouse
Immunogen: synthetic peptide. The epitope recognized by A303-384A-T maps to a region between residue 375 and 419 of mouse Interferon Regulatory Factor 3 using the numbering given in entry NP_058545.1 (GeneID 54131).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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