Anti-Integrin Beta-4, clone UM-A9

Anti-Integrin Beta-4, clone UM-A9
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2163SAF-100UG 100 µg - -

3 - 10 business days*

578.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. This antibody recognizes a protein of... more
Product information "Anti-Integrin Beta-4, clone UM-A9"
1 mg/ml in sterile PBS, BSA free, sodium azide free. This antibody recognizes a protein of 205kDa, which is identified as integrin beta 4 (ITGB4) and CD104. Its epitope is localized in the extracellular domain of integrin beta 4 protein. Integrins are heterodimers comprised of a and b subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of a and b polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Protein function: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. [The UniProt Consortium]
Keywords: Anti-GP150, Anti-CD104, Anti-ITGB4, Anti-Integrin beta-4, Integrin Beta-4 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2163SAF

Properties

Application: FC, IF, FA (blocking)
Antibody Type: Monoclonal
Clone: UM-A9
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta-4 / CD104 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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