Anti-Integrin, alpha 1 (Integrin alpha-1, ITGA1, CD49 Antigen-like Family Member A, CD49a, CD49a Ant

Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that unctions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 06-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a -terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation ites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of esenchymal stem cell proliferation and cartilage production. It also plays an essential role in the egulation of MSC proliferation and cartilage production. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.