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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ4291 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Insulin-degrading enzyme, also known as... more
Product information "Anti-IDE / Insulin degrading enzyme"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Protein function: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. [The UniProt Consortium]
Keywords: | Anti-IDE, Anti-Insulysin, Anti-Insulinase, EC=3.4.24.56, Anti-Insulin protease, Anti-Abeta-degrading protease, Anti-Insulin-degrading enzyme, IDE Antibody / Insulin degrading enzyme |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ4291 |
Properties
Application: | WB, FC, IHC (paraffin), ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | A recombinant human protein corresponding to amino acids F485-K756 was used as the immunogen for the IDE antibody. |
Format: | Purified |
Database Information
KEGG ID : | K01408 | Matching products |
UniProt ID : | P14735 | Matching products |
Gene ID | GeneID 3416 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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