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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32338-100 | 100 µl | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Inducible T cell co-stimulator (ICOS), also known as CD278, is a glycoprotein and member of the... more
Product information "Anti-ICOS/CD278 (C-Term) Rabbit Monoclonal Antibody (RM417)"
Inducible T cell co-stimulator (ICOS), also known as CD278, is a glycoprotein and member of the CD28/B7 family of co-stimulatory receptors that promotes T cell activation. It exists as a membrane-bound disulfide-linked homodimer and contains a leader peptide, an extracellular domain that interacts with ICOS ligand (ICOSL), and a cytoplasmic tail that mediates association with PI3K and is critical for T cell activation. ICOS is expressed on activated CD4+ and CD8+ T cells following T cell receptor crosslinking and/or co-stimulation by CD28. ICOS co-stimulation of T cells induces production of IL-4, IL-5, IL-6, IFN-gamma (Cay-32008, Cay-32078), TNF-alpha (Cay-32020, Cay-32069), and GM-CSF (Cay-32044, Cay-32079), but not IL-2, and superinduces production of IL-10, as well as prevents T cell apoptosis. Human melanoma cells express ICOSL and promote the expansion of ICOS+ IL-10-secreting regulatory T cells, which is positively correlated with unfavorable clinical outcomes. Administration of an anti-ICOS monoclonal antibody ameliorates mucosal inflammation and damage in a mouse model of T helper cell-induced chronic colitis. Cayman's ICOS/CD278 (C-Term) Rabbit Monoclonal Antibody (RM417) can be used for immunohistochemistry (IHC) applications.Synonyms: Activation-inducible Lymphocyte Immunomediatory Molecule, Inducible T cell Co-Stimulator. Immunogen: Peptide from the C-terminal region of human ICOS. Clone Designation: RM417. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC. Cross Reactivity: (+) ICOS.
Keywords: | Activation-inducible Lymphocyte Immunomediatory Molecule, Inducible T cell Co-Stimulator |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32338 |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | RM417 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Peptide from the C-terminal region of human ICOS |
Format: | Purified |
Database Information
KEGG ID : | K06713 | Matching products |
UniProt ID : | Q9Y6W8 | Matching products |
Gene ID | GeneID 29851 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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