Anti-Human S-100 Protein, clone 4C4.9 (Monoclonal) [Mouse]

S-100 protein has been found in normal m elanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells.1,2,6 Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly.1-4 A large number of well differentiated tumors of the salivary gland, adipose and cartilaginous tissue, 3 and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.4,5 Despite the fact that S-100 protein is an ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly melanomas. Protein function: Probably acts as a Ca(2+) signal transducer (PubMed:22399290). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (PubMed:22399290). [The UniProt Consortium]