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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay24530-300 | 300 µg | - |
6 - 10 business days* |
488.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Heat shock protein 27 (Hsp27), also known as heat shock protein beta-1 (HspB1), is a member of... more
Product information "Anti-Hsp27 (HspB1)"
Heat shock protein 27 (Hsp27), also known as heat shock protein beta-1 (HspB1), is a member of the small heat shock protein (sHSP) family that is upregulated during conditions of cellular stress including heat shock, radiation, hypoxia, and exposure to reactive oxygen species (ROS). It is composed of an N-terminal domain, a highly conserved alpha-crystallin domain, and a C-terminal domain. Hsp27 functions as a molecular chaperone to prevent protein aggregation in an ATPase-independent manner. This chaperone activity is altered by changes in oligomerization state or by post-translational modifications including phosphorylation at serine residues 15 and 82, which increases affinity for damaged polypeptides in response to heat shock. Hsp27 also works in complex with other chaperone proteins, such as Hsp70 (Cay-22739, Cay-23002), to correct misfolded proteins. This protein also plays a role in apoptosis, proteasome activation, cell differentiation, and has been shown to interact with actin and intermediate filaments. Mutations in HSPB1 have been linked to hereditary neuromuscular diseases and cause Charcot-Marie-Tooth Disease Type 2 (CMT-2). Cayman's Hsp27 (HspB1) Polyclonal Antibody can be used for ELISA, Immunofluorescence, Immunohistochemistry, and Western blot applications. The antibody recognizes Hsp27 (HspB1) at 25 kDa from human samples.Synonyms: Estrogen-regulated 24 kDa protein, Heat Shock 27 kDa Protein, Heat Shock Protein 27, Heat Shock Protein beta-1, SRP27, Stress-responsive Protein 27. Immunogen: Human recombinant Hsp27(HspB1). MW: 25.5 kDa. Formulation: (Request formulation change), 300 µg of protein-A purified Hsp27 (HspB1) polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: ELISA, IF, IHC, and WB. UniProt Accession #: P04792.
Keywords: | Anti-HSPB1, Anti-HSP27, Anti-HspB1, Anti-SRP27, Anti-HspB1, Anti-SRP27, Anti-HSP 27, Anti-HSP 27, Anti-Heat shock protein beta-1, Anti-28 kDa heat shock protein, Anti-Heat shock 27 kDa protein, Anti-Heat shock protein beta-1, Anti-28 kDa heat shock protei |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24530 |
Properties
Application: | ELISA, IF, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Human recombinant Hsp27(HspB1) |
Database Information
KEGG ID : | K04455 | Matching products |
UniProt ID : | P04792 | Matching products |
Gene ID | GeneID 3315 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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