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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
036776-FITC.200 | 200 µl | - | - |
3 - 19 business days* |
993.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme... more
Product information "Anti-HSD11B2, ID (HSD11B2, HSD11K, Corticosteroid 11-beta-dehydrogenase isozyme 2, 11-beta-hydroxyst"
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. Applications: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-500, Immunohistochemistry: 1:50-100, Flow Cytometry: 1:10-50, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Keywords: | Anti-11-DH2, Anti-HSD11K, Anti-HSD11B2, EC=1.1.1.-, Anti-11-beta-HSD, Anti-11-beta-HSD2, Anti--HSD11 type II, Anti-11-beta-hydroxysteroid dehydrogenase type 2, Anti-11-beta-hydroxysteroid dehydrogenase type II |
Supplier: | United States Biological |
Supplier-Nr: | 036776-FITC |
Properties
Application: | FLISA, FC, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | FITC |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | HSD11B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284~314 amino acids from the Central region of human HSD11B2. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K00071 | Matching products |
UniProt ID : | P80365 | Matching products |
Gene ID | GeneID 3291 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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