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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR)... more
Product information "Anti-HEY1"
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. Protein function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). [The UniProt Consortium]
Keywords: | Anti-HEY1, Anti-HRT-1, Anti-CHF-2, Anti-hHRT1, Anti-HESR-1, Anti-BHLHB31, Anti-bHLHb31, Anti-HES-related repressor protein 1, Anti-Hairy-related transcription factor 1, Anti-Cardiovascular helix-loop-helix factor 2, HEY1 Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-66694 |
Properties
Application: | IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | A synthetic peptide of human HEY1 (NP_001269780.1). |
Database Information
KEGG ID : | K09091 | Matching products |
UniProt ID : | Q9Y5J3 | Matching products |
Gene ID | GeneID 23462 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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You will get a certificate here
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