Anti-HAS2, ID (HAS2, Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2) (Azi

Anti-HAS2, ID (HAS2, Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2) (Azi
Item number Size Datasheet Manual SDS Delivery time Quantity Price
036432-HRP.200 200 µl - -

3 - 19 business days*

731.00€
 
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide... more
Product information "Anti-HAS2, ID (HAS2, Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2) (Azi"
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. Applications: Suitable for use in Western Blot, Immunohistochemistry ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Immunohistochemistry: 1:50-100, Storage and Stability:, Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Keywords: Anti-HAS2, EC=2.4.1.212, Anti-HA synthase 2, Anti-Hyaluronan synthase 2, Anti-Hyaluronate synthase 2, Anti-Hyaluronic acid synthase 2
Supplier: United States Biological
Supplier-Nr: 036432-HRP

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: HRP
Host: Rabbit
Reactivity: Human
Immunogen: HAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the Central region of human HAS2.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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