Anti-GRLF1/p190RhoGAP

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-736A-T 20 µl (2 blots) -

3 - 9 business days

125.00€
A301-736A-M 100 µl (10 blots) -

3 - 9 business days

299.00€
A301-736A 100 µl (20 µg) -

3 - 9 business days

443.00€
 
Protein function: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds... more
Product information "Anti-GRLF1/p190RhoGAP"
Protein function: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis. Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation. Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation. During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth. Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3', this function is however unclear and would need additional experimental evidences (PubMed:1894621). [The UniProt Consortium]
Keywords: Anti-GRF-1, Anti-p190-A, Anti-Rho GAP p190A, Anti-Rho GTPase-activating protein 35, Anti-Glucocorticoid receptor repression factor 1, Anti-Glucocorticoid receptor DNA-binding factor 1
Supplier: Bethyl Laboratories
Supplier-Nr: A301-736A-T

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Dog)
Immunogen: synthetic peptide. The epitope recognized by A301-736A-T maps to a region between residue 1200 and 1250 of human glucocorticoid receptor DNA binding factor 1 (p190RHOGAP) using the numbering given in entry EAW57452.1 (GeneID 2909).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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