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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G8170-41A4.20 | 20 µl | - | - |
3 - 19 business days* |
439.00€
|
||
G8170-41A4.100 | 100 µl | - | - |
3 - 19 business days* |
757.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen... more
Product information "Anti-Glycogen Synthase Kinase 3 alpha, beta (GSK3a/b, GSK3 beta, GSK-3 beta, GSK3b)"
Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3 alpha and Ser9 of GSK-3 beta (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5). GSK-3 alpha regulates the production of amyloid-beta peptides, a major component of the plaques that accumulate with progression of Alzheimer disease. Administration of therapeutic concentrations of lithium, a GSK-3 inhibitor, attenuates amyloid-beta production by specifically inhibiting the cleavage of amyloid precursor protein (APP) by upsilon-secretase, blocking accumulation of amyloid-beta peptides in the brains of mice that overproduce APP (6). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted antibody in TBS, 5% BSA, 0.1% Tween-20 at 4°C with gentle shaking, overnight. , Immunoprecipitation: 1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | EC=2.7.11.1, EC=2.7.11.26, Anti-GSK-3 alpha, Anti-Glycogen synthase kinase-3 alpha, Anti-Serine/threonine-protein kinase GSK3A |
Supplier: | United States Biological |
Supplier-Nr: | G8170-41A4 |
Properties
Application: | IP, WB |
Antibody Type: | Monoclonal |
Clone: | 10E25(D75D3) |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | hamster, human, monkey, mouse, rat |
Immunogen: | Synthetic peptide surrounding Gln269 of human GSK-3 Alpha (KLH-coupled). |
Database Information
KEGG ID : | K08822 | Matching products |
UniProt ID : | P49840 | Matching products |
Gene ID | GeneID 2931 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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