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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1... more
Product information "Anti-FANCL"
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. Protein function: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. [The UniProt Consortium]
Keywords: | Anti-PHF9, Anti-FANCL, Anti-FAAP43, Anti-Fanconi anemia group L protein, Anti-E3 ubiquitin-protein ligase FANCL, Anti-RING-type E3 ubiquitin transferase FANCL, Anti-Fanconi anemia-associated polypeptide of 43 kDa, FANCL Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-62470 |
Properties
Application: | WB, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Recombinant protein of human FANCL |
Database Information
KEGG ID : | K10606 | Matching products |
UniProt ID : | Q9NW38 | Matching products |
Gene ID | GeneID 55120 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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