Anti-EIF6 / EIF3A

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R32150 100 µg - -

3 - 10 business days

503.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. EIF6 (Eukaryotic Translation Initiation... more
Product information "Anti-EIF6 / EIF3A"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. EIF6 (Eukaryotic Translation Initiation Factor 6), also called EIF3A or ITGB4BP, is a human gene. By fluorescence in situ hybridization, Sanvito et al. (1998) mapped the ITGB4BP gene to 20q11.2. Ceci et al. (2003) demonstrated that the ribosomal 60S subunit is activated by release of EIF6. In the cytoplasm, EIF6 is bound to free 60S but not to 80S subunits. Furthermore, EIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C. Gandin et al. (2008) demonstrated that mammalian eIF6 is required for efficient initiation of translation in vivo. Eif6-null mouse embryos were lethal at preimplantation. Heterozygous mice had 50% reduction of eIF6 levels in all tissues, and showed reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression. Protein function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. [The UniProt Consortium]
Keywords: Anti-CAB, Anti-EIF3A, Anti-eIF-6, Anti-p27(BBP), Anti-B(2)GCN homolog, Anti-B4 integrin interactor, Anti-Eukaryotic translation initiation factor 6, EIF6 Antibody / EIF3A
Supplier-Nr: R32150

Properties

Application: WB, IHC (paraffin), ICC
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Amino acids 66-210 of human EIF6/EIF3A were used as the immunogen for the EIF3A antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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