Anti-E2-25K

Anti-E2-25K
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-125A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A304-125A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A304-125A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to... more
Product information "Anti-E2-25K"
Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B, in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein- dependent degradation of RB1. [The UniProt Consortium]
Keywords: Anti-HIP2, Anti-UBE2K, Anti-HIP-2, Anti-Ubiquitin-protein ligase, Anti-Ubiquitin carrier protein, Anti-Huntingtin-interacting protein 2, Anti-E2 ubiquitin-conjugating enzyme K, Anti-Ubiquitin-conjugating enzyme E2 K
Supplier: Bethyl Laboratories
Supplier-Nr: A304-125A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Bovine)
Immunogen: synthetic peptide. The epitope recognized by A304-125A-T maps to a region between residue 150 to 200 of human Ubiquitin-Conjugating Enzyme E2K using the numbering given in entry NP_005330.1 (GeneID 3093).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-E2-25K"
Write a review
or to review a product.
Viewed