Anti-HIP2, C-terminal

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG63591.100 100 µg - -

6 - 14 business days*

784.00€
 
Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to... more
Product information "Anti-HIP2, C-terminal"
Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B, in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein- dependent degradation of RB1. [The UniProt Consortium]
Keywords: Anti-HIP2, Anti-UBE2K, Anti-HIP-2, EC=6.3.2.19, Anti-Ubiquitin-protein ligase, Anti-Ubiquitin carrier protein, Anti-Huntingtin-interacting protein 2, Anti-Ubiquitin-conjugating enzyme E2 K, Anti-Ubiquitin-conjugating enzyme E2-25K
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG63591

Properties

Application: ELISA, IHC (paraffin), WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Species reactivity: human (Expected: mouse, canine, swine, bovine)
Immunogen: C-SWDVETATELLLSN
Format: Ammonium Sulfate Precipitated

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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