Anti-Drosha

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-886A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A301-886A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is... more

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Product information "Anti-Drosha"

Protein function: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. [The UniProt Consortium]

Keywords:	Anti-RN3, Anti-p241, Anti-DROSHA, Anti-RNase III, Anti-Ribonuclease 3, Anti-Protein Drosha, Anti-Ribonuclease III
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-886A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: rabbit, guinea pig, orangutan, gorilla, chimpanzee, african elephant, thirteen-lined ground squirrel)
Immunogen:	synthetic peptide. The epitope recognized by A301-886A-T maps to a region between residue 1324 and 1374 of human double-stranded RNA-specific endoribonuclease using the numbering given in entry NP_037367.3 (GeneID 29102).
Format:	Antigen Affinity Purified