Anti-CYP19A1 / Aromatase

Anti-CYP19A1 / Aromatase
Anti-CYP19A1 / Aromatase
Anti-CYP19A1 / Aromatase
Anti-CYP19A1 / Aromatase
Anti-CYP19A1 / Aromatase
Anti-CYP19A1 / Aromatase
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Save 30% on all primary antibodies by Arigo Biolaboratories!

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*1 Offer expires 16/12/2024
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
ARG41572.50 50 µg - -

6 - 14 business days*

30 %
520.00€
364.00€
 
Protein function: A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens,... more
Product information "Anti-CYP19A1 / Aromatase"
Protein function: A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247). Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid (PubMed:20385561). Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen (PubMed:22773874). Also displays 2-hydroxylase activity toward estrone (PubMed:22773874). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR, NADPH-ferrihemoprotein reductase) (PubMed:20385561, PubMed:22773874). [The UniProt Consortium]
Keywords: Anti-ARO1, Anti-CYPXIX, Anti-Aromatase, Anti-Estrogen synthase, Anti-Cytochrome P450 19A1, Anti-Cytochrome P-450AROM
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG41572

Properties

Application: FC, IHC (paraffin), WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant protein corresponding to Y241-H503 of Human CYP19A1 / Aromatase
MW: 58 kD
Format: Antigen Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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