71 products were found matching "K07434"!

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cyp19a1b, or cytochrome P four five zero family nineteen subfamily A polypeptide one b, is an aromatase enzyme that catalyzes the conversion of androgens into estrogens. In zebrafish, Cyp19a1b is the brain-specific isoform of aromatase and plays a key role in...

Aminoglutethimide is an aromatase inhibitor (IC50 = 7.5 µM). Aromatase inhibitors, including aminoglutethimide, inhibit estrogen synthesis via aromatase, suppressing estrogen levels in post-menopausal women. Formulations containing aromatase inhibitors have been used to treat estrogen receptor-positive breast cancer...

Exemestane is an irreversible inhibitor of aromatase (Ki = 26 nM). It is selective for aromatase over 5alpha-reductase when used at a concentration of 30 µM. Subcutaneous administration of exemestane (3-100 mg/kg per day) decreases tumor proliferation in rats with mammary tumors induced by the carcinogenic...

Anastrozole is an aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1). It is selective for aromatase/CYP19A1 over the cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 µM). Anastrozole (0.1 mg/kg) blocks ovulation in mature female rats and...

A steroidal aromatase inhibitor.

Protein function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. [The UniProt Consortium]

Letrozole is a potent, cell-permeable inhibitor of aromatase (IC50 = 2 nM). It inhibits proliferation of estrogen receptor-positive (ER+) MCF-7 cells when used alone at concentrations ranging from 0.1 to 100 nM and when used at a concentration of 10 nM in combination with testosterone or 4-androstene-3,17-dione. It...

Fadrozole is a non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively). It selectively inhibits estrogen over progesterone production induced by luteinizing hormone (LH) in hamster ovarian tissue as well as corticosterone and aldosterone...

Aromatase inhibitor.

Letrozole-d4 is intended for use as an internal standard for the quantification of letrozole (Cay-11568) by GC- or LC-MS. Letrozole is a potent, cell-permeable inhibitor of aromatase (IC50 = 2 nM). It inhibits proliferation of estrogen receptor-positive (ER+) MCF-7 cells when used alone at concentrations ranging...

Protein function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. [The UniProt Consortium]