47 products were found matching "K07434"!

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The CYP19A1 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ARO. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ARO. Next,...

5alpha-Androstan-3,6,17-trione is an analog of 4-androstene-3,6,17-trione (4-AT, 6-OXO), an irreversible aromatase inhibitor that is used to increase serum androgen levels. 5alpha-Androstan-3,6,17-trione is considered a designer drug and is regulated in the United States. The physiological and toxicological...

4-hydroxy Androstenedione (4-HAD) is a steroidal inhibitor of aromatase (also known as cytochrome P450 19A1, Ki = 27 nM). As aromatase catalyzes the conversion of androgens to estrogens, aromatase inhibitors, including 4-HAD, are used against hormone-sensitive breast cancer in menopausal women. They are also abused...

Aminoglutethimide is an aromatase inhibitor (IC50 = 7.5 µM). Aromatase inhibitors, including aminoglutethimide, inhibit estrogen synthesis via aromatase, suppressing estrogen levels in post-menopausal women. Formulations containing aromatase inhibitors have been used to treat estrogen receptor-positive breast cancer...

Exemestane is an irreversible inhibitor of aromatase (Ki = 26 nM). It is selective for aromatase over 5alpha-reductase when used at a concentration of 30 µM. Subcutaneous administration of exemestane (3-100 mg/kg per day) decreases tumor proliferation in rats with mammary tumors induced by the carcinogenic...

Anastrozole is an aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1). It is selective for aromatase/CYP19A1 over the cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 µM). Anastrozole (0.1 mg/kg) blocks ovulation in mature female rats and...

A steroidal aromatase inhibitor.

Letrozole is a potent, cell-permeable inhibitor of aromatase (IC50 = 2 nM). It inhibits proliferation of estrogen receptor-positive (ER+) MCF-7 cells when used alone at concentrations ranging from 0.1 to 100 nM and when used at a concentration of 10 nM in combination with testosterone or 4-androstene-3,17-dione. It...

Protein function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. [The UniProt Consortium]

Fadrozole is a non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively). It selectively inhibits estrogen over progesterone production induced by luteinizing hormone (LH) in hamster ovarian tissue as well as corticosterone and aldosterone...

Aromatase inhibitor.