Anti-CrkRS

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-679A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A301-679A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the... more

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Product information "Anti-CrkRS"

Protein function: Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. [The UniProt Consortium]

Keywords:	Anti-CRK7, Anti-CrkRS, Anti-CDK12, Anti-hCDK12, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 12, Anti-CDC2-related protein kinase 7, Anti-Cell division protein kinase 12, Anti-Cdc2-related kinase, arginine/serine-rich
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-679A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat)
Immunogen:	synthetic peptide. The epitope recognized by A301-679A-T maps to a region between residue 1 and 50 of human cell division cycle 2 (CDC2)-related kinase arginine/serine-rich using the numbering given in entry NP_057591.2 (GeneID 51755).
Format:	Antigen Affinity Purified