- Search results for K08819
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34 products were found matching "K08819"!
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Item number: Cay39158-10
SR 4835 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13. It binds to Cdk12 and Cdk13 (Kds = 98 and 4.9 nM, respectively) and inhibits Cdk12- and Cdk13-dependent phosphorylation of RNA polymerase II in MDA-MB-231 cells (EC50 = 105.5 nM). SR 4835 inhibits the proliferation of MDA-MB-231, MDA-MB-468, Hs...
Keywords: | N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine |
Application: | Cdk12 / Cdk13 inhibitor |
CAS | 2387704-62-1 |
MW: | 499.4 D |
From 48.00€
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Item number: Cay39564-10
BSJ-4-116 is a proteolysis-targeting chimera (PROTAC) composed of a modified form of the multi-kinase degrader TL12-186 linked to the cereblon ligand and PROTAC synthetic intermediate E3 ligase ligand 2 (Cay-36664). It induces time- and concentration-dependent degradation of cyclin-dependent kinase 12 (Cdk12) in...
Keywords: | N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6... |
Application: | PROTAC, Cdk12 degradation |
CAS | 2519823-34-6 |
MW: | 837.4 D |
From 188.00€
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Item number: A301-458A
Protein function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation....
Keywords: | Anti-CDC2L, Anti-CDK13, Anti-hCDK13, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 13, Anti-CDC2-related... |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: A301-679A-T
Protein function: Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic...
Keywords: | Anti-CRK7, Anti-CrkRS, Anti-CDK12, Anti-hCDK12, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 12,... |
Application: | WB, IP |
Host: | Rabbit |
Species reactivity: | human |
From 164.00€
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Item number: Cay26386-1
THZ531 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13 (IC50s = 158 and 69 nM for Cdk12/cyclin K and Cdk13/cyclin K, respectively). It is selective for Cdk12/cyclin K and Cdk13/cyclin K over Cdk9/cyclin T1 and Cdk7/cyclin H/MAT1 (IC50s = 10.5 and 8.5 µM, respectively). THZ531 inhibits proliferation...
Keywords: | (2E)-N-[4-[[(3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-piperidinyl]carbonyl]phenyl]-4-(dimethylamino)-2-bu... |
Application: | CDK12 inhibitor, CDK13 inhibitor |
CAS | 1702809-17-3 |
MW: | 558.1 D |
From 60.00€
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Item number: G-HUFI02005.96
Application: | ELISA |
Species reactivity: | human |
641.00€
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Item number: LKT-R5774.10
Roscovitine is an inhibitor of CDKs (1, 2, 5, 7, 9, 12) and L-type Ca2+ channels, it exhibits anti-inflammatory and anticancer activities. Roscovitine resolves neutrophil-driven inflammation. In B-cell lymphoma cells, roscovitine induces cell cycle arrest and apoptosis and inhibits proliferation.
Keywords: | Seliciclib, CYC202 |
Application: | CDK inhibitor |
CAS | 186692-46-6 |
MW: | 354.45 D |
From 156.00€
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Item number: BPS-101128-1
Complex of human CDK13 (cyclin dependent kinase 13) and human cyclin K. The proteins were co-expressed in Sf9 insect cells along with S. cerevisiae CAK1 (Serine/threonine-protein kinase CAK1). Recombinant human CDK13, encompassing amino acids 516-1512 (end), contains an N-terminal GST-tag. Recombinant human Cyclin...
Keywords: | CDK13, CDC2L, hCDK13, EC=2.7.11.22, EC=2.7.11.23, Cyclin-dependent kinase 13, CDC2-related protein kinase 5, Cell division... |
Application: | Kinase research |
Expressed in: | insect cells |
Origin: | human |
MW: | 138+90 kD |
From 371.00€
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Item number: G-CAB10258.100
Application: | WB |
Host: | Rabbit |
Species reactivity: | human |
From 352.00€
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Item number: G-CAB14894.100
WB 1:500 - 1:2000. Protein function: Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance...
Keywords: | Anti-CRK7, Anti-CDK12, Anti-CrkRS, Anti-hCDK12, EC=2.7.11.22, EC=2.7.11.23, Anti-Cyclin-dependent kinase 12,... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 352.00€
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Item number: ATA-HPA008038.100
Protein function: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic...
Keywords: | Anti-CRK7, Anti-CrkRS, Anti-CDK12, Anti-hCDK12, EC=2.7.11.23, EC=2.7.11.22, Anti-Cyclin-dependent kinase 12,... |
Application: | ICC, IHC |
Host: | Rabbit |
Species reactivity: | human |
From 300.00€
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Item number: ATA-HPA059241.100
Protein function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation....
Keywords: | Anti-CDC2L, Anti-CDK13, Anti-hCDK13, EC=2.7.11.23, EC=2.7.11.22, Anti-Cyclin-dependent kinase 13, Anti-CDC2-related... |
Application: | ICC |
Host: | Rabbit |
Species reactivity: | human |
From 300.00€
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