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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-1065-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1).... more
Product information "Anti-CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker)(Clone: CPS1/1022)"
This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors. Protein function: Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. [The UniProt Consortium]
Keywords: | Anti-CPS1, Anti-CPSase I, Anti-Carbamoyl-phosphate synthetase I, Anti-Carbamoyl-phosphate synthase [ammonia], mitochondrial, Monoclonal Antibody to CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker)(Clone: CPS1/1022) |
Supplier: | Abeomics |
Supplier-Nr: | 36-1065 |
Properties
Application: | IF, IHC |
Antibody Type: | Monoclonal |
Clone: | CPS1/1022 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, dog |
Immunogen: | Recombinant human CPS1 protein |
Format: | Affinity Purified |
Database Information
KEGG ID : | K01948 | Matching products |
UniProt ID : | P31327 | Matching products |
Gene ID | GeneID 1373 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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