Anti-CoCoA

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-818A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-818A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR).... more

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Product information "Anti-CoCoA"

Protein function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). [The UniProt Consortium]

Keywords:	Anti-PP13275, Anti-KIAA1536, Anti-CALCOCO1, Anti-Calphoglin, Anti-Sarcoma antigen NY-SAR-3, Anti-Coiled-coil coactivator protein, Anti-Calcium-binding and coiled-coil domain-containing protein 1
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-818A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat, orangutan)
Immunogen:	synthetic peptide. The epitope recognized by A300-818A-T maps to a region between residue 650 and the C-terminus (residue 691) of human Coiled-Coil Transcriptional Coactivator 1 using the numbering given in entry NP_065949.1 (GeneID 57658).
Format:	Antigen Affinity Purified