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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-2877-20 | 20 µg | - |
3 - 11 business days* |
375.00€
|
|||
ABE-36-2877-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD73 (also designated ecto-5'-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a... more
Product information "Anti-CD73 (Immuno-Oncology Target) Monoclonal Antibody (Clone: NT5E/2505)"
CD73 (also designated ecto-5'-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function throµgh differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins. Protein function: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. [The UniProt Consortium]
Keywords: | Anti-NT5, Anti-NT5E, Anti-CD73, Anti-5'-NT, EC=3.1.3.5, Anti-5'-nucleotidase, Anti-Ecto-5'-nucleotidase, Anti-CD73 (Immuno-Oncology Target) Monoclonal Antibody (Clone: NT5E/2505) |
Supplier: | Abeomics |
Supplier-Nr: | 36-2877 |
Properties
Application: | WB, FC, IF, IHC |
Antibody Type: | Monoclonal |
Clone: | NT5E/2505 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant full length human NT5E protein |
Database Information
KEGG ID : | K19970 | Matching products |
UniProt ID : | P21589 | Matching products |
Gene ID | GeneID 4907 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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