Anti-CD40 (TNF receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw

CD40 is a glycoprotein important for T-B lymphocytes interactions. The ligand for CD40 is CD154 (CD40L). The function of CD40 is involved in growth, differentiation, and isotype-switching on B cells and also involved to rescue B cells from apoptosis. CD40 is a 48kD type I single chain trans- membrane glycoprotein expressed on normal and neoplastic B cells, but not on terminally differentiated plasma cells. CD40 antigen is also present on Hodgkin's and Reed-Sternberg cells, follicular dendritic cells, some macrophages, basal epithelial cells and endothelial cells. , Applications: Suitable for use in Flow Cytometry and ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.