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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C2446-79B.500 | 500 µg | - | - |
3 - 19 business days* |
508.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
VCAM-1 is an adhesion molecule and a major mediator of the inflammatory response. It is expressed... more
Product information "Anti-CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1, INCAM-110), FITC conjugated, clone 1.BB.619"
VCAM-1 is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (i.e., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein. The monoclonal antibody immunoprecipitates a peptide that gives a single band on SDS-PAGE gels with an apparent Mr of ~100kD under reducing conditions and 92kD under nonreducing conditions (1-5). Applications: Identification and enumeration of CD106 cells by flow cytometry (1-5), Identification of VCAM-1+ cells by immunofluorescence and immunohistochemical staining (1-5), Blockage of lymphocyte adhesion in Whitlock-Witte long-term bone marrow cultures (1, 2), Inhibition of lymphopoiesis in Whitlock-Witte cultures (1, 2), Immunoprecipitation (1), Recommended Dilution: Flow Cytometry: < 1ug/10e6 cells, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: | United States Biological |
Supplier-Nr: | C2446-79B |
Properties
Application: | FC, IF, IHC, IP |
Antibody Type: | Monoclonal |
Clone: | 5K220 |
Conjugate: | FITC |
Host: | Rat |
Species reactivity: | mouse |
Format: | Purified |
Database Information
Handling & Safety
Storage: | -20°C (frozen cool packs!) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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