Anti-Beclin-1 (Beclin 1 (Coiled-coil Moesin-like BCL2-interacting Protein), Beclin1, BECN1, APG6, AT

Anti-Beclin-1 (Beclin 1 (Coiled-coil Moesin-like BCL2-interacting Protein), Beclin1, BECN1, APG6, AT
Item number Size Datasheet Manual SDS Delivery time Quantity Price
B0981-23T.100 100 µl - -

3 - 19 business days*

546.00€
 
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor... more
Product information "Anti-Beclin-1 (Beclin 1 (Coiled-coil Moesin-like BCL2-interacting Protein), Beclin1, BECN1, APG6, AT"
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biological processes in which autophagy is important such as cell differentiation and nutritional stress responses. Applications: Suitable for use in Western Blot, Immunofluorescence, Immunohistochemistry (paraffin). Other applications not tested. Recommended Dilution: Western Blot: 1:2000-1:5000, a band is seen at ~52 kD, Immunofluorescence: mouse tissue, Optimal dilution determined by the researcher. Storage and Stability: Store at 2-8°C. Do Not Freeze! Aliquots are stable for at least 3 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
Keywords: Anti-BECN1, Anti-GT197
Supplier: United States Biological
Supplier-Nr: B0981-23T

Properties

Application: IF, IHC, WB
Antibody Type: Polyclonal
Conjugate: HRP
Host: Rabbit
Reactivity: Human
Immunogen: Internal synthetic peptide to human Beclin 1, containing residues within 1-100. Cellular Localization: Cell Membrane, Cytoplasmic and Golgi Apparatus. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.
Format: Affinity Purified

Handling & Safety

Storage: +4°C (do not freeze!)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Beclin-1 (Beclin 1 (Coiled-coil Moesin-like BCL2-interacting Protein), Beclin1, BECN1, APG6, AT"
Write a review
or to review a product.
Viewed