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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
B0981-23T.100 | 100 µl | - | - |
3 - 19 business days* |
742.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor... more
Product information "Anti-Beclin-1 (Beclin 1 (Coiled-coil Moesin-like BCL2-interacting Protein), Beclin1, BECN1, APG6, AT"
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biological processes in which autophagy is important such as cell differentiation and nutritional stress responses. Applications: Suitable for use in Western Blot, Immunofluorescence, Immunohistochemistry (paraffin). Other applications not tested. Recommended Dilution: Western Blot: 1:2000-1:5000, a band is seen at ~52 kD, Immunofluorescence: mouse tissue, Optimal dilution determined by the researcher. Storage and Stability: Store at 2-8°C. Do Not Freeze! Aliquots are stable for at least 3 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
Keywords: | Anti-BECN1, Anti-GT197 |
Supplier: | United States Biological |
Supplier-Nr: | B0981-23T |
Properties
Application: | IF, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | HRP |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Internal synthetic peptide to human Beclin 1, containing residues within 1-100. Cellular Localization: Cell Membrane, Cytoplasmic and Golgi Apparatus. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K08334 | Matching products |
UniProt ID : | Q14457 | Matching products |
Gene ID | GeneID 8678 | Matching products |
Handling & Safety
Storage: | +4°C (do not freeze!) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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