Anti-Beclin 1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG58688.100	100 µl		-	-	6 - 14 business days*		658.00€

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Protein function: Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as... more

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Product information "Anti-Beclin 1"

Protein function: Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. [The UniProt Consortium]

Keywords:	Anti-BECN1, Anti-GT197
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG58688

Properties

Application:	ICC, IF, IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Synthetic peptide derived from Human Beclin 1
MW:	52 kD
Format:	Affinity Purified